Out-of-control, trash-talking buddy cops Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force reunite, and bullets fly, cars crash and laughs explode as they pursue a whacked-out drug lord from the streets of Miami to the barrios of Cuba. But the real fireworks result when Marcus discovers that playboy Mike is secretly romancing Marcus’ sexy sister.

Marcus and Mike are forced to confront new threats, career changes, and midlife crises as they join the newly created elite team AMMO of the Miami police department to take down the ruthless Armando Armas, the vicious leader of a Miami drug cartel.