Deadpool tells the origin story of former Special Forces operative turned mercenary Wade Wilson, who after being subjected to a rogue experiment that leaves him with accelerated healing powers, adopts the alter ego Deadpool. Armed with his new abilities and a dark, twisted sense of humor, Deadpool hunts down the man who nearly destroyed his life.

After losing Vanessa (Morena Baccarin), the love of his life, 4th-wall breaking mercenary Wade Wilson aka Deadpool (Ryan Reynolds) must assemble a team and protect a young, full-figured mutant Russell Collins aka Firefist (Julian Dennison) from Cable (Josh Brolin), a no-nonsense, dangerous cyborg from the future, and must also learn the most important lesson of all: to be part of a family again.